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Acute and chronic lesions of the oral mucosa including recurrent ulcerative aphthous stomatitis; Erosive lichen planus; denture stomatitis; traumatic lesions including denture sore spots; desquamative gingivitis and stomatitis. Lesions of traumatic origin and most nonrecurring conditions heal rapidly and permanently. Chronic and recurrent lesions are promptly relieved, but symptoms usually recur after termination of therapy. However, Kenalog in Orabase is effective in suppressing subsequent recurrences.

Congestive heart failure - Lanoxin is useful regardless of whether the failure is predominantly of the left or right ventricle, or involves both sides of the heart. It is particularly useful in heart failure resulting from chronic overload (hypertension, valvular lesions, atherosclerotic heart disease) in which the supply of energy is not impaired. Lanoxin does not cause major benefit in situations in which the metabolic energy supply is compromised as in thyrotoxicosis, hypoxia, and severe thiamine deficiency. Atrial fibrillation - Because Lanoxin depresses conduction in the atrioventricular bundle, producing a slower ventricular beat, it is valuable in atrial fibrillation. It will frequently convert atrial flutter into fibrillation and, upon withdrawal of the drug, normal sinus rhythm may be restored. Paroxysmal atrial tachycardia - Lanoxin may relieve or prevent an attack, but its use in paroxysmal ventricular tachycardia is dangerous.

Congestive heart failure - Lanoxin is useful regardless of whether the failure is predominantly of the left or right ventricle, or involves both sides of the heart. It is particularly useful in heart failure resulting from chronic overload (hypertension, valvular lesions, atherosclerotic heart disease) in which the supply of energy is not impaired. Lanoxin does not cause major benefit in situations in which the metabolic energy supply is compromised as in thyrotoxicosis, hypoxia, and severe thiamine deficiency. Atrial fibrillation - Because Lanoxin depresses conduction in the atrioventricular bundle, producing a slower ventricular beat, it is valuable in atrial fibrillation. It will frequently convert atrial flutter into fibrillation and, upon withdrawal of the drug, normal sinus rhythm may be restored. Paroxysmal atrial tachycardia - Lanoxin may relieve or prevent an attack, but its use in paroxysmal ventricular tachycardia is dangerous.

Acute myeloblastic leukaemia. Less commonly, chronic granulocytic (myelocytic, myeloid, myelogenous) leukaemia. Although superior results are generally obtained with busulphan (Myleran) in the treatment of chronic granulocytic leukaemia. LANVIS may be useful during blast crises or periods of thrombocytopenia induced by busulphan or other therapy. A degree of cross resistance exists between LANVIS (thioguanine) and Puri-Nethol (mercaptopurine) and generally it is not to be expected that patients who no longer respond to mercaptopurine will respond to thioguanine or vice versa. Unlike mercaptopurine the detoxification of LANVIS is not dependent on xanthine oxidase, hence therapy with LANVIS is not affected by the xanthine oxidase inhibitor, allopurinol (Zyloprim). Recent evidence suggests that LANVIS is particularly useful in concurrent or sequelist combination with other antineoplastic drugs, e.g., cytosine arabinoside. Not effective for the treatment of chronic lymphocytic leukaemia or solid tumours. The aim of therapy is to achieve normal appearance of the bone marrow and peripheral blood. It is recognised, however, that in treating acute leukaemia, one may not always be able to achieve complete remissions and must be satisfied with partial improvement.

Treatment of Hodgkin's disease, certain forms of non-Hodgkin's lymphoma, chronic lymphocytic leukaemia, Waldenstrom's macroglobulinaemia, advanced ovarian adenocarcinoma. LEUKERAN has a significant effect in a proportion of patients with breast cancer.

Minocycline may be used for the treatment of infections caused by any of the following organisms provided that they have been shown by bacteriological testing to be susceptible to minocycline: Escherichia coli, Enterobacter aerogenes, Haemophilus influenzae, Klebsiella and Proteus. It may also be used in the treatment of infections due to Streptococcus pyogenes (group A ?- haemolytic) and Streptococcus faecalis but because a large proportion of these organisms is resistant to tetracyclines, minocycline should be used only if the organisms have been shown to be definitely sensitive. Tetracyclines, including minocycline, are not the drugs of choice in the treatment of staphylococcal infections. Minocycline may be considered for the treatment of such infections only if other suitable agents are not available and the organism has been shown to be sensitive to minocycline. Minocycline may be used in the treatment of tetracycline-resistant acne.